Reactive oxygen in fruit flies acts as a cell signalling mechanism for immune...
(PhysOrg.com) -- For years, health conscious people have been taking antioxidants to reduce the levels of reactive oxygen in their blood and prevent the DNA damage done by free radicals, which are the...
View ArticleScientists find missing puzzle piece of powerful DNA repair complex
Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that...
View ArticleHeat forms potentially harmful substance in high-fructose corn syrup
Researchers have established the conditions that foster formation of potentially dangerous levels of a toxic substance in the high-fructose corn syrup (HFCS) often fed to honey bees. Their study, which...
View ArticleLoss of Tumor-Suppressor and DNA-Maintenance Proteins Causes Tissue Demise,...
(PhysOrg.com) -- A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR,...
View ArticleResearchers use drug-radiation combo to eradicate lung cancer
Researchers at UT Southwestern Medical Center have eliminated non-small cell lung (NSCL) cancer in mice by using an investigative drug called BEZ235 in combination with low-dose radiation.
View ArticleNanoparticles may cause DNA damage across a cellular barrier
(PhysOrg.com) -- Scientists have shown in the laboratory that metal nanoparticles damaged the DNA in cells on the other side of a cellular barrier. The research, by the University of Bristol, is...
View ArticleTwo proteins act as molecular tailors in DNA repair
(PhysOrg.com) -- On average, our cells encounter a very lethal form of DNA damage 10 times a day. Lucky for us, we have the capacity to repair each and every one of them. New research now reveals...
View ArticleHow cells tolerate DNA damage -- start signal for cell survival program...
Cancer researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have gained new insights into how cells react to DNA damage. Dr. Michael Stilmann, Dr. Michael Hinz and...
View ArticleProtecting the future: How plant stem cells guard against genetic damage
Scientists at the John Innes Centre in Norwich, UK, have shown how plants can protect themselves against genetic damage caused by environmental stresses. The growing tips of plant roots and shoots have...
View ArticleArsenic biomethylation required for oxidative DNA damage
Biomethylation of arsenic compounds appears to cause oxidative DNA damage and to increase their carcinogenicity, according to a new study published online November 23 in the Journal of the National...
View ArticleSmall addition to cancer drug may make big difference
University of Florida researchers have found a way to use just a fraction of the normal dosage of a highly toxic, debilitating chemotherapy drug to achieve even better results against colon cancer cells.
View ArticleWhy cancer cells just won't die (w/ Video)
When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A cancer researcher at Robarts Research...
View ArticleCritical protein helps mend damaged DNA
In order to preserve our DNA, cells have developed an intricate system for monitoring and repairing DNA damage. Yet precisely how the initial damage signal is converted into a repair response remains...
View ArticleExcess DNA damage found in cells of patients with Friedreich's ataxia
Elevated levels of DNA damage have for the first time been found in the cellular mitochondria and nuclei of patients with the inherited, progressive nervous system disease called Friedreich's ataxia...
View ArticleUnwanted guests: How herpes simplex virus gets rid of the cell's security guards
A viral infection is like an uninvited, tenacious houseguest in the cell, using a range of tricks to prevent its eviction. Researchers at the Salk Institute for Biological Studies have identified one...
View ArticleEnhancing arrest of cell growth to treat cancer in mice
A team of researchers, led by Pier Paolo Pandolfi, at Beth Israel Deaconess Medical Center, Boston, has identified a new type of cellular senescence (i.e., irreversible arrest of cell growth) and...
View ArticleCells can read damaged DNA without missing a beat
Scientists have shown that cells' DNA-reading machinery can skim through certain kinds of damaged DNA without skipping any letters in the genetic "text." The studies, performed in bacteria, suggest a...
View ArticleCancer breakthrough could save children’s lives
(PhysOrg.com) -- A cancer which claims the lives of thousands of children worldwide every year is a step closer to being cured thanks to a breakthrough by scientists at Newcastle University.
View ArticleResearchers discover second protective role for tumor-suppressor
ATM, a protein that reacts to DNA damage by ordering repairs or the suicide of the defective cell, plays a similar, previously unknown role in response to oxidative damage outside of the nucleus,...
View ArticleUnpacking condensins' function in embryonic stem cells
Regulatory proteins common to all eukaryotic cells can have additional, unique functions in embryonic stem (ES) cells, according to a study in the February 22 issue of the Journal of Cell Biology. If...
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